Molecular Biology

We seek better understanding of the molecular basis for cell dysfunction when blood supply is critically reduced such that cell death is minimized, and especially so in settings of cardiac arrest. Accordingly, one laboratory is devoted to research on heart cell replacement when there are muscle cells that are lost during the global ischemic injury of cardiac arrest leading to life threatening post resuscitation myocardial dysfunction.

Research on shock has been extended to include shock states caused by bleeding and other volume deficits. This has led it to reexamine the role of blood transfusion and various drug interventions for resuscitation with which to preserve function when blood flow is critically restrained.