Development of automated external defibrillators and especially  optimal waveforms and capacitor use, together with software applications pertinent to lay use of defibrillators.

  A device utilizing existing ECG electrodes for distinguishing pulselesness and respiratory arrest, especially for rescuers. 

  A compact mechanical chest compressor to facilitate victim transport with uninterrupted CPR.

  Methods for pharmacological induction of "hibernation" to  minimize global ischemic injury of circulatory shock and cardiac  arrest. 

  Transnasal echo-Doppler techniques for non-invasive hemodynamic monitoring as alternatives to flow directed  pulmonary artery catheters.

  Development and application of a new technology for tissue capnometry, including under-the-tongue measurement of tissue carbon dioxide for diagnosis, monitoring, and estimation of the severity of circulatory shock.  Extension of capnographic methods for intra-operative detection of border zone between "live" and "dead" tissue.

  Development of more optimal adrenergic drugs for CPR.

  Optimization of timing of defibrillation during CPR, the "AMSA" predictor.

  Methods of pharmacological preconditioning to minimize myocardial injury during cardiac arrest.

  Development of a Resuscitation Blanket, which allows uninterrupted precordial compression without risk of discomfort or injury to the rescuer caused by electrical shocks.

  Models in the rat for investigation of mechanisms and therapy of septic shock.

  A mouse model of cardiac arrest in support of genetic studies on global myocardial ischemia in "knock-out" mice.

  Vascular interface for both withdrawal of blood for automated “real time” laboratory measurements and for automated infusion of fluids and drugs.

  Visualization of the microcirculation during shock states and cardiac resuscitation to better understand the relationships  between the macro and microcirculation.