The Institute of Critical Care Medicine was founded in 1961 by Doctors Max Harry Weil and the late Herbert S. Shubin as a non-profit public foundation at the University of Southern California School of Medicine. It was incorporated in the State of California in 1975. The Institute’s predecessor in 1959 initiated the nation’s first cardiovascular resuscitation ward as part of the USC School of Medicine at the Los Angeles County/USC Medical Center, and at the USC sponsored Center of the Critically Illat Hollywood Presbyterian Medical Center.

In 1981, the group moved to the University of Health Sciences/Chicago Medical School . In 1991, the international headquarters of the Institute of Critical Care Medicine was opened in Palm Springs , CA. It is an affiliate of the Keck School of Medicine of the University of Southern California and the Desert Regional Medical Center of Palm Springs and the University of Health Sciences/Chicago Medical School. Dr. Weil continues professional appointments atUSC, Northwestern University Medical School, University of Pittsburgh, and at the Eisenhower Medical Center in Rancho Mirage.

With the completion of the new international headquarters in Rancho Mirage, the Institute moved to its current headquarters in 2004. At the end of 2006, Dr. Weil retired from the administrative duty. To honor his substantial contributions to the Institute, based on the recommendation of the H.N. and Francis C. Berger Foundation, the Board of Trustees of the Institute renamed the Institute to The Weil Institute of Critical Care Medicine. Collaborative clinical research has been arranged with major university medical centers and especially with former trainees and associates. Such collaborative programs have been sponsored in Trieste, Italy; Toronto, Canada; Basel, Switzerland; Haifa, Israel; Sao Paulo, Brazil; Shanghai and Guangzhou, China; Caracas, Venezuela; Brussels, Belgium; Santiago, Chile; Amsterdam, The Netherlands; Slovenia, Czechoslovakia; Taipei, Taiwan; New York, New York; and Indianapolis, Indiana. To conduct world-wide studies, WICCM is linked by computer to more than 1,000 study beds, gathering valuable patient data for clinical research on critical illnesses, injuries and especially on the benefits of new treatments.